Urolithin A is a compound produced by gut bacteria from precursors found in pomegranates and some nuts, studied for its effect on mitochondrial health through a process called mitophagy (recycling of damaged mitochondria). Not everyone's gut bacteria produce it efficiently, which is part of the rationale for supplementing it directly.
Urolithin A has a comparatively more developed evidence base than some longevity supplements, with some human trials suggesting improvements in muscle mitochondrial health and endurance markers. It is still an emerging area, and long-term outcome benefits are not established.
Appears well tolerated in the human studies conducted so far. Long-term safety data remains limited.
If you have a chronic condition or take regular medication, discuss before starting. The muscle and mitochondrial findings are promising but early, not a proven longevity outcome.
Higher, sold as a monthly supply, often branded.
Human trials on urolithin A and mitochondrial/muscle health. Educational information only.