Spermidine is a compound found in foods like wheat germ, aged cheese and soy, studied for its role in autophagy, the cellular recycling process associated with healthy ageing. It has become a popular longevity supplement on the strength of this mechanism.
Spermidine's role in autophagy is genuinely interesting, and observational studies link higher dietary spermidine intake to better health outcomes. However, evidence that supplements replicate these dietary associations, and produce meaningful longevity benefit in humans, is early and not established.
Appears well tolerated in the limited data available. Long-term safety of supplemental doses (as opposed to dietary intake) is not well characterised.
The longevity claims rest largely on mechanism and observational dietary data, not on strong supplement trials. If you take regular medication, check for interactions. Not an established intervention.
Moderate to higher, sold as a monthly supply, often as wheat germ extract.
Research on spermidine and autophagy. Observational studies on dietary spermidine. Educational information only. Supplement benefit not firmly established.