DHEA (dehydroepiandrosterone) is a hormone produced by the adrenal glands that serves as a precursor your body can convert into testosterone and oestrogen. Levels decline steadily with age, which has driven interest in DHEA as a supplement, though its effects in supplement form are less clear-cut than the natural hormone's role.
Evidence is mixed and context-dependent. Some studies show modest benefits for specific groups, such as improved bone density or wellbeing in older adults with clinically low DHEA, or use in certain fertility contexts under medical supervision. Evidence for general anti-ageing or performance benefits in healthy adults is weak and inconsistent.
Because DHEA converts to sex hormones, it can affect hormone-sensitive conditions. Potential side effects include acne, hair changes, and hormonal shifts. It is a controlled or prescription substance in some jurisdictions, and quality varies in unregulated supplement markets.
Before use, especially if you have a history of hormone-sensitive cancer (breast, prostate, ovarian), are pregnant or breastfeeding, or have a hormonal condition. Because DHEA influences multiple hormonal pathways, self-directed use without clinical indication and appropriate testing is generally not recommended.
Varies by dose and source.
Peer-reviewed research on DHEA supplementation in ageing and hormone-sensitive conditions. Endocrine Society guidance on DHEA use. Educational information only. Speak to a qualified healthcare professional before starting.